Mario Rodríguez may refer to:
Sports Association football Mario Rodríguez (footballer, born 1937) (1937–2015), Argentine footballer Mario Rodríguez (footballer, born 1960), Chilean footballer Mario Rodríguez (footballer, born 1972), Peruvian footballer Mario César Rodríguez (born 1975), Honduran footballer Mario-Ernesto Rodríguez (born 1976), Uruguayan-Italian footballer Mario Rodríguez (footballer, born 1978), Mexican footballer Mario Rodríguez (footballer, born 1981), Guatemalan footballer Mario Rodríguez (footballer, born 1991), Mexican footballer Mario Rodríguez (soccer, born 1994), American soccer player for Dynamo Dresden Mario Rodríguez (footballer, born 1995), Mexican footballer Mario Rodríguez (footballer, born 1997), Spanish footballer
Other sports Mario Rodríguez (baseball) (1909–?), Cuban baseball player Mario Rodríguez (weightlifter), Dominican Republic Olympic weightlifter Mario Rodriguez (fencer) (born 1959), American Paralympic fencer Mario Rodríguez (boxer) (born 1988), Mexican professional boxer
Others Mario Rodríguez Cobos (1938–2010), Spanish-Argentine writer and spiritual leader