James McCusker may refer to:
Sir James McCusker (banker) (1913–1994), Australian financier and philanthropist James Harold McCusker (1940–1990), Northern Ireland Ulster Unionist Party politician James L. McCusker (1869–?), American swimmer Jim McCusker (American football) (1936–2015), American football defensive tackle Jim McCusker (footballer) (1939–2023), Northern Irish footballer Jim McCusker (trade unionist) (born 1943), Northern Ireland trade union leader