Jerome Ysroael Lettvin (February 23, 1920 – April 23, 2011), often known as Jerry Lettvin, was an American cognitive scientist, and Professor of Electrical and Bioengineering and Communications Physiology at the Massachusetts Institute of Technology (MIT). He is best known as the lead author of the paper, "What the Frog's Eye Tells the Frog's Brain" (1959),Lettvin, J.Y; Maturana, H.R.; McCulloch, W.S.; Pitts, W.H., What the Frog's Eye Tells the Frog's Brain , Proceedings of the IRE, Vol. 47, No. 11, November 1959 one of the most cited papers in the Science Citation Index. He wrote it along with Humberto Maturana, Warren McCulloch and Walter Pitts, and in the paper they gave special thanks and mention to Oliver Selfridge at MIT."We are particularly grateful to O. G. Selfridge, whose experiments with mechanical recognizers of pattern helped drive us to this work and whose criticism in part shaped its course." Lettvin carried out neurophysiological studies in the spinal cord, made the first demonstration of "feature detectors" in the visual system, and studied information processing in the terminal branches of single axons. Around 1969, he originated the term "grandmother cell"Gross, Charles G., Genealogy of the "Grandmother Cell" , NEUROSCIENTIST 8(5):512–518, 2002. to illustrate the logical inconsistency of the concept.
Lettvin was also the author of many published articles on subjects varying from neurology and physiology to philosophy and politics.Jerome Lettvin page Among his many activities at MIT, he served as one of the first directors of the Concourse Program, and, along with his wife Maggie, was a houseparent of the Bexley dorm.
Early life
Lettvin was born February 23, 1920, in Chicago, the eldest of four children (including the pianist Theodore Lettvin) of Solomon and Fanny Lettvin, Jewish immigrants from Ukraine. After training as a neurologist and psychiatrist at the University of Illinois (BS, MD 1943),Annual register, University of Illinois, Urbana-Champaign campus (p.451) he practiced medicine during the Battle of the Bulge.Squire, Larry R., The History of Neuroscience in Autobiography, Volume 2, Society for Neuroscience, 1998. Cf. pp. 223-243 on Jerome Lettvin. After the war, he continued practicing neurology and researching nervous systems, partly at Boston City Hospital, and then at MIT with Walter Pitts and Warren McCulloch under Norbert Wiener.
Scientific philosophy
Lettvin considered any experiment a failure from which the experimental animal does not recover to a comfortable happy life. He was one of the very few neurophysiologists who successfully recorded pulses from unmyelinated vertebrate axons. His main approach to scientific observation seems to have been reductio ad absurdum, finding the least observation that contradicts a key assumption in the proposed theory. This led to some unusual experiments. In the paper "What the Frog's Eye Tells the Frog's Brain", he took a major risk by proposing feature detectors in the retina. When he presented this paper at a conference, he was laughed off the stage by his peers, yet for the next ten years it was the single most cited scientific paper. MIT Technology Review described this experiment:
For Lettvin, a corollary to finding contradictions was taking risks: the bigger the risk, the likelier a new finding. Robert Provine quotes him as asking, "If it does not change everything, why waste your time doing the study?"
Lettvin was an outspoken critic of pseudo-scientific practices relied upon by many of the social sciences, as well as the potential threat posed by Artificial Intelligence. His presentation at the 1971 UNESCO symposium on Culture and Science titled The Diversity of Cultures as against the Universality of Science and Technology opens with the statement that “The comprehensive involvement of man in science is now fatal” and closes with the warning “For this is the new rationalism, the new messiah, the new church, and the new dark ages come upon us."
Lettvin made a careful study of the work of Leibniz, discovering that he had constructed a mechanical computer in the late 17th century.
Lettvin is also known for his friendship with, and encouragement of the cognitive scientist and logician Walter Pitts, a polymath who first showed the relationship between the philosophy of Leibniz and universal computing in "A Logical Calculus of Ideas Immanent in Nervous Activity," a seminal paper Pitts co-authored with Warren McCulloch.
Lettvin continued to research the properties of nervous systems throughout his life, culminating in his study of ion dynamics in axon cytoskeleton.
Politics
Lettvin was a firm advocate of individual rights and heterogeneous society. His father nurtured these views with ideas from Kropotkin's book Mutual Aid. Lettvin became an expert witness in trials in both the United States and in Israel, always on behalf of individual rights.
During the anti-war demonstrations of the 1960s, Lettvin helped to negotiate agreements between police and protesters, and in 1968 he took part in the student takeover of the MIT Student Center in support of an AWOL soldier."Six-Day M.I.T. Sanctuary Ends Quietly Without Bust", The Harvard Crimson, Monday, November 04, 1968 He deplored the making of laws based on false science and false statistics, and the distortion of observations for political or economic advantage.
When the American Academy of Arts and Sciences withdrew its award of the annual Emerson-Thoreau medal from Ezra Pound because of his vocal support for Italian Fascism, Lettvin resigned from the Academy and wrote in his resignation letter: "It is not art that concerns you but politics, not taste but special interest, not excellence but propriety."
Debating
On May 3, 1967, in the Kresge Auditorium at MIT, Lettvin debated with Timothy Leary about the merits and dangers of LSD. Leary took the position that LSD is a beneficial tool in exploring consciousness. Lettvin took the position that LSD is a dangerous molecule that should not be used."Leary and Lettvin Clash on Drugs In M.I.T. Debate", The Harvard Crimson, Thursday, May 4, 1967Collins, Bud, "LSD Lion Loses to M.I.T. Mauler", The Boston Globe, November 24, 1967. N.B. later reprinted in Collins, Bud, "LSD Lion Loses to M.I.T. Mauler", Psychiatric Quarterly, Volume 42, Number 1 (1968), 104-106,
Lettvin was a regular invitee at the Ig Nobel Prize ceremony as "the world's smartest man," and debated extemporaneously against groups of people on their own subjects of expertise.
Personal life Lettvin married his wife, Maggie Lettvin in 1947. They had three children: David, Ruth, and Jonathan.
Death Lettvin died on April 23, 2011, in Hingham, Massachusetts at the age of 91.
Published papers Year Title, Publication, Issue; Contributing Authors 1943 A Mathematical Theory of the Affective Psychoses, Bulletin of Mathematical Biophysics, Vol. 5; (with Pitts) 1948 Somatic Functions of the Central Nervous System, Annual Review of Physiology Vol. 10; (with McCulloch) 1948 The Path of Suppression in the Spinal Grey Matter, Federation Proceedings, Vol. 7, No. 1, March; (with McCulloch) 1950 An Electrical Hypothesis of Central Inhibition and Facilitation, Proceedings of the Association for Research in Nervous and Mental Diseases, Vol. 30, December; (with McCulloch, Pitts, and Dell) 1950 Positivity in Ventral Horn During Bulbar Reticular Inhibition of Motoneurons Federation Proceedings, Vol. 9, No. 1, March; (with Dell and McCulloch) 1951 Changes Produced in the Central Nervous System by Ultrasound, Science, Vol. 114, No. 2974; (with Wall, Fry, Stephens, and Tucker) 1952 Sources and Sinks of Current in the Spinal Cord, Federation Proceedings, Vol. 11, No. 1, March; (with Pitts and Brazier) 1953 Comparaison entre les machines à calculer et le cerveau, Les machines à calculer et la pensée humaine, Vo.l. 37, pp. 425–443; (with McCulloch, Pitts, and Dell) 1953 On Microelectrodes for Plotting Currents in Nervous Tissue, Proceedings of the Physiological Society, Vol. 122; (with Howland, McCulloch, Pitts, and Wall) 1954 Maps Derived by Bipolar Microelectrode Stimulation Within the Spinal Cord, Federation Proceedings, Vol. 13, March; (with Pitts, McCulloch, Wall, and Howland) 1955 Physiology of a Primary Chemoreceptor Unit, Science, Vol. 122, No. 3166, September; (with Hodgson and Roeder) 1955 Reflex Inhibition by Dorsal Root Interaction, Journal of Neurophysiology, vol.18; (with Howland, McCulloch, Pitts, and Wall) 1955 Effects of Strychnine, with Special Reference to Spinal Afferent Fibers, Epilepsia, Series III, Vol. 4; (with Wall, McCulloch, and Pitts) 1955 The Terminal Arborisation of the Cat's Pyramidal Tract Determined by a New Technique, The Yale Journal of Biology and Medicine, Vol. 28, Nos. 3-4, Dec.-Feb.; (with Wall, McCulloch, and Pitts) 1956 Excitability Changes in Anatomical Components of the Monosynaptic Arc Following Tetanic Stimulation, Federation Proceedings, Vol. 15, No. 1, March; (with McCulloch and Pitts) 1956 Limits on Nerve Impulse Transmission, IRE Convention Record, National, Part 4, March 19–20; (with Wall, Pitts, and McCulloch) 1956 Central Effects of Strychnine on Spinal Afferent Fibers, A.M.A. Archives of Neurology and Psychiatry, Vol. 75: 323-324; (with McCulloch, Pitts, and Wall) 1957 Membrane Currents in Clamped Vertebrate Nerve, Nature, Vol. 180, pp. 1290–1291, Dec. 7; (with McCulloch, and Pitts) 1956/1957 Footnotes on a Headstage, IRE Transactions on Medical Electronics; (with Howland and Gesteland) 1956 Evidence that Cut Optic Nerve Fibers in a Frog Regenerate to their Proper Places in the Tectum, Science, Vol. 130, No. 3390, December; (with Maturana, McCulloch, and Pitts) 1959 How Seen Movement Appears in the Frog's Optic Nerve, Federation Proceedings Vol. 18, No. 1, March; (with Maturana, Pitts, and McCulloch) 1959 What the Frog's Eye Tells the Frog's Brain, Proceedings of the IRE, Vol. 47, No. 11, November; (with Maturana, McCulloch, and Pitts) 1959 Comments on Microelectrodes, Proceedings of the IRE, Vol. 47, No. 11, November; (with Gesteland, Howland, and Pitts) 1959 Number of Fibers in the Optic Nerve and the Number of Ganglion Cells in the Retina of Anurans, Nature, Vol. 183, pp. 1406–1407, May 16; (with Maturana) 1959 Bridge for Measuring the Impedance of Metal Microelectrodes, The Review of Scientific Instruments, Vol. 30, No. 4, April; (with Gesteland and Howland) 1960 Anatomy and Physiology of Vision in the Frog (Rana pipiens), The Journal of General Physiology, Vol. 43, No. 6, Supplement pp. 129–175; (with Maturana, McCulloch, and Pitts) 1961 Two Remarks on the Visual System of the Frog, Research Laboratory of Electronics, MIT, Vol. 38; (with Maturana, Pitts, and McCulloch) 1962 Translations of Poems by Morgenstern, The Fat Abbot, Fall/Winter 1962 1963 Odor Specificities of the Frog's Olfactory Receptors, Proceedings of the First International Symposium on Olfaction and Taste (Pergamon Press); (with Gesteland, Pitts, and Rojas) 1964 A Theory of Passive Ion Flux through Axon Membranes, Nature, Vol. 202, No. 4939, pp. 1338–1339, June; (with Pickard, McCulloch, and Pitts) 1964 Microelectrodes Research Laboratory of Electronics, MIT Encyclopedia of Electrochemistry, (Reinhold Publishing Corporation: New York), pp. 822–826; (with Gesteland, Howland, and Pitts) 1964 Receptor Model of the Frog's Nose, NEREM Record; (with Gesteland) 1964 Caesium Ions Do Not Pass the Membrane of the Giant Axon, Proceedings of the National Academy of Sciences, Vol. 52, No. 5, pp. 1177–1183; (with Pickard, Moore, Takata, Pooler, and Bernstein) 1964? Lanthanum Simulates High Calcium and Reduces Conductance Changes in Nerve Membranes, XXIII International Congress of Physiological Sciences; (with Moore, Takata, and Pickard) 1964 Passive Transport of Ions Across Nerve membranes, Minutes of the APS-NES 1964 Spring Meeting of the New England Section, 4 April; (with Pickard)