Bifunctional apoptosis regulator is an enzyme that in humans is encoded by the BFAR gene. This enzyme is embedded in the membrane of the endoplasmic reticulum where it is involved in regulating and inhibiting apoptosis (controlled cell death). It acts as a E3 ubiquitin ligase, and is involved in the ubiquitination or degradation of the proteins Bax inhibitor 1, TGF beta receptor 1, and PNPLA3.
Function Enables caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Acts upstream of or within negative regulation of apoptotic process.
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