Puffy can refer to:

People Charles Puffy (1884–1942/1943), Hungarian film actor Sean Combs (born 1969), American rapper and entrepreneur Mike Bordin (born 1962), American drummer for the rock band Faith No More Jeff Dubay (born 1968), Minnesota sports talk radio personality

Other uses Puffy AmiYumi, a Japanese pop duo Puffy: P.S. I Love You, 1999 PlayStation game featuring Puffy AmiYumi Puffy (mascot), the mascot of the free operating system OpenBSD Puffy planet, a class of gas giant planets that have a very low density Puffy Lake, a lake in Manitoba, Canada – see Sherridon, Manitoba

See also Puff (disambiguation)