Empress Isabella or Empress Isabel may refer to:
Isabella of England (1214–1241), empress consort of Frederick II, Holy Roman Emperor Isabella of Portugal (1503–1539), empress consort of Charles V, Holy Roman Emperor Isabel Moctezuma (1509/1510–1550/1551), empress consort of Cuitláhuac, later of Cuauhtémoc, Aztec emperors
See also Queen Isabella (disambiguation) Empress Elisabeth (disambiguation) Isabel, Princess Imperial of Brazil (1846–1921), titular Empress of Brazil