3-Hydroxy-3-methylglutaryl-CoA lyase

A 3-Hydroxy-3-methylglutaryl-CoA lyase (), or HMG-CoA lyase, is a type of enzyme that catalyzes the chemical reaction:

(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

In humans, there are two known isoforms: HMG-CoA lyase, mitochondrial (sometimes just called HMG-CoA lyase) which is encoded by the HMGCL gene, and HMG-CoA lyase, cytoplasmic, encoded by the gene HMGCLL1 (and sometimes referred to as HMGCL-like 1). This enzyme catalyzes a key step in ketogenesis, and is also involved in breaking down leucine.

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