Alanine aminotransferase 1, also ambiguously called Glutamate—pyruvate transaminase, is an enzyme that in humans is encoded by the GPT gene. This enzyme is a type of alanine aminotransferase involved in production of glucose in the body (gluconeogenesis) and the metabolism of amino acids. This form of alanine aminotransferase is found in the cytoplasm of the cell and highly expressed in the liver, which differs from alanine aminotransferase 2 which is found in the mitochondria.
Function As an alanine aminotransferase, this enzyme catalyses the following reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
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