Wetherspoon is a surname. Notable people with the surname include:
John Wetherspoon (1844–1928), Scottish-born farmer and politician in New South Wales, Australia Aaron Wetherspoon, a King of the Cage champion in mixed martial arts
See also Wetherspoons (J D Wetherspoon plc), a British pub company Weatherspoon, a surname Witherspoon (surname) Wotherspoon, a surname