Spironolactone/hydrochlorothiazide, sold under the brand name Aldactazide among others, is a fixed-dose combination medication used for the treatment of hypertension (high blood pressure). It contains spironolactone, an aldosterone antagonist and potassium-sparing diuretic; and hydrochlorothiazide, a thiazide diuretic and antihypertensive.

Spironolactone/hydrochlorothiazide was approved for medical use in the United States in 1961. It is available as a generic medication.

Medical uses Spironolactone/hydrochlorothiazide is indicated for the treatment of congestive heart failure; cirrhosis of the liver accompanied by edema and/or ascites; nephrotic syndrome; and essential hypertension.

Society and culture Legal status Spironolactone/hydrochlorothiazide was approved for medical use in the United States in 1961.

Names Spironolactone/hydrochlorothiazide is sold under the brand name Aldactazide.

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