UCD0830, also known as N,N-dimethyl-2-aminotetralin (N,N-DiMe-2-AT), is a serotonin receptor modulator of the 2-aminotetralin family. It is the N,N-dimethyl derivative of 2-aminotetralin (2-AT) and is a cyclized phenethylamine as well as a partial ergoline.
Pharmacology UCD0830 is a potent partial agonist of the serotonin 5-HT2C receptor, with an of 167nM and an of 52%. It is selective for activation of this receptor over the serotonin 5-HT2A and 5-HT2B receptors, where it shows no significant agonism at concentrations of up to 10,000nM. However, UCD0830 shows weak but detectable affinity for the serotonin 5-HT2A receptor (Ki = 2,290nM). In accordance with its lack of serotonin 5-HT2A receptor agonism, UCD0830 did not produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. Other behavioral effects in animals have also been described.
Chemistry The chemical synthesis of UCD0830 has been described.
History UCD0830 was first described in the scientific literature by 1980. Subsequently, it was studied and described in greater detail by David E. Olson and colleagues at the University of California, Davis in 2026.
See also Substituted 2-aminotetralin Cyclized phenethylamine Partial ergoline UCD0829 MDMAT
References
External links N,N-DiMe-2-AT - Isomer Design