UCD0068, also known as des-B-LSD, is a putatively non-hallucinogenic serotonin receptor modulator related to the psychedelic drug LSD. It is a simplified or partial lysergamide and is the deconstructed analogue of LSD in which the B ring (the pyrrole component of the indole ring) has been removed. The drug can also be thought of as a cyclized phenethylamine.
Pharmacology UCD0068 shows weak affinity for the serotonin 5-HT2A receptor (Ki = 890nM). The drug's affinity for this receptor was 166-fold lower than that of LSD. UCD0068 acts as a moderate-to-high efficacy partial agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors. Its and values at these receptors were found to be 104nM (60%) at the serotonin 5-HT2A receptor, 9.24nM (61%) at the serotonin 5-HT2B receptor, and 176nM (89%) at the serotonin 5-HT2C receptor. The drug was 188-fold, 17-fold, and 283-fold less potent as an agonist of these receptors than LSD, respectively. Hence, it is a relatively selective serotonin 5-HT2B receptor agonist.
In contrast to LSD and another partial lysergamide known as UCD0120 (dides-B,C-LSD), UCD0068 failed to induce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. As such, UCD0068 would be expected to be non-hallucinogenic in humans.
Chemistry
The chemical synthesis of UCD0068 has been described. A variety of other deconstructed analogues of LSD along with UCD0068 have also been described.
History
UCD0068 was first described in the scientific literature by Zenichi Horii and colleagues by 1967. Subsequently, it was studied and described in greater detail by David E. Olson and colleagues at the University of California, Davis in 2026.
See also Partial lysergamide
References
External links UCD0068 - Isomer Design