Manuel Mantilla was a Venezuelan politician. Throughout his career, he served as the appointed governor of Miranda and as a minister in the governments of Rómulo Betancourt, Raúl Leoni, and Carlos Andrés Pérez.
Biography Mantilla was a member of the Democratic Action party. In September 1963, he was appointed Minister of Interior during the second government of Rómulo Betancourt (1959–1964), a position he held until March 1964.
During the presidency of Raúl Leoni (1964–1969), he served as the Secretary of the Presidency and was described by journalist Carlos Rangel as "the man closest to President Leoni and the most powerful man in that government after the president". He took part in a meeting where it was decided to condemn Cuba at the Organization of American States over the Machurucuto raid in 1967.
During the first presidency of Carlos Andrés Pérez (1974–1979), he was appointed governor of Miranda and later returned to his post as Minister of Interior.
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