Ann-Sophie is a feminine given name. Notable people with the name include:
Ann-Sophie Barwich, assistant professor at Indiana University Bloomington Ann-Sophie Bettez (born 1987), Canadian ice hockey forward Ann-Sophie Bohm-Eisenbrandt, German politician Ann-Sophie Duyck (born 1987), Belgian triathlete Ann-Sophie Taschereau (born 2002), Canadian weightlifter Ann-Sophie Qvarnström, Swedish illustrator