Giaccone is a surname. Notable people with the surname include:
Andrea Giaccone, Italian politician Enrico Giaccone (1896–1923), Italian racing driver Giuseppe Giaccone (1900–1986), Italian football goalkeeper Lautaro Giaccone (born 2001), Argentine football attacking midfielder Mario Giaccone (born 1945), Italian sporting director and former amateur road cyclist Paolo Giaccone, Italian forensic pathologist Philip Giaccone (1932–1981), American mobster