John Weiss may refer to:
People John Weiss (1818–1879), American author John Weiss (American football) (1921–1990), American football player John Weiss (1933–2018), jewellery designer, wife of Althea McNish
Other uses John Weiss & Son, firm of London-based surgical instrument makers
See also Jonathan M. Weiss (born 1942), American scholar