Tagliacozzi () is an Italian surname, derived from the town of Tagliacozzo. Notable people with the surname include:
Gaspare Tagliacozzi (1545–1599), Italian surgeon Giovanni dei Tagliacozzi (died 1540), Italian Roman Catholic prelate Nicola Tagliacozzi Canale (1691–1764), Italian architect, engineer, engraver and scenic designer
See also Eric Tagliacozzo (born 1967), American historian and academic