Nyamekye is a Ghanaian surname. Notable people with the surname include:
Anna Nyamekye (born 1954), Ghanaian politician Blay Nyamekye Armah (born 1974), Ghanaian lawyer and politician Eric Nyamekye (born 1965), Ghanaian Pentecostal televangelist Nyamekye Awortwie-Grant (born 2000), German footballer Stella Nyamekye (born 2005), Ghanaian footballer