Desio is an Italian commune.
Desio may also refer to:
People Ardito Desio (1897–2001), Italian explorer, mountain climber, geologist, and cartographer Carlos Desio (born 1973), Argentine football manager and former player, brother of Hermes Desio Giovanni Battista Desio (1628–1677), Italian Roman Catholic prelate and Bishop of Venosa Hermes Desio (born 1970), Argentine former footballer Javier Ortega Desio (born 1990), Argentine rugby union player
Other uses Battle of Desio, a 1277 battle for control of Milan Desio railway station, serving the commune
See also De Sio, a surname