Aquilina is a surname. Notable people with the surname include:
Brendan Aquilina (born 1987), Maltese lawn and indoor bowler Edward Aquilina (1945–2021), Maltese football player and manager John Aquilina (born 1950), Australian politician Joseph Aquilina (1911–1997), Maltese author and linguist Joseph John Aquilina (born 1957), football player and manager Karol Aquilina (born 1979), Maltese politician and lawyer Lauren Aquilina (born 1995), English singer-songwriter Mario Aquilina (born 1975), Maltese sailor Mike Aquilina, American author and journalist Pawlu Aquilina (1929–2009), Maltese poet and writer Richard Aquilina (1953–2006), Maltese football player Rosemarie Aquilina (born 1958), American judge Thomas Aquilina (born 2001), Australian football player Tony Aquilina (1950–2003), Australian politician