A diazabicyclooctane β-lactamase inhibitor is a novel class of β-lactamase inhibitors (BLIs) that contain a strained urea functional group imbedded within the diazabicyclooctane (DBO) ring system. This strained urea acts as a warhead that reacts with the active site serine residue in β-lactamases. The main use of this class of BLIs is to restore β-lactam antibiotic activity against resistant Gram-negative bacteria when it is co-administered.
Avibactam is the founding member of this class of drugs. Other drugs in this class include durlobactam, nacubactam, pilabactam, pralurbactam, relebactam, and zidebactam.
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