Leitz is a German and Dutch cognominal surname. It derives from the personal name , a pet form of any of various Germanic compound names formed with . Notable people with the surname include:

Ernst Leitz II (1871–1956), German businessman and humanitarian Ernst Leitz I, father of Ernst Leitz II Elsie Kuehn-Leitz, daughter of Ernst Leitz II Nick Leitz (born 1996), American racing driver Christian Leitz (born 1960), German Egyptologist Louis Leitz (1846–1918), German mechanic and entrepreneur

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