The 2025–26 Coupe de France preliminary rounds, Grand Est was the qualifying competition to decide which teams from the leagues of the Grand Est region of France took part in the main competition from the seventh round.
A total of twenty teams qualified from the Grand Est preliminary rounds.
In the 2024–25 edition of the competition, both FCSR Haguenau of Championnat National 2 and ES Thaon of Championnat National 3 progressed furthest, making it to the round of 32 before losing out. Thaon were beaten by Ligue 1 side RC Strasbourg Alsace on penalties, whilst Haguenau lost 1–3 at home to Ligue 2 side USL Dunkerque.
Draws and Fixtures On 18 July 2025 the league published the draw for the first round of the competition. The draw consisted of 343 ties featuring teams from district divisions and two from the third tier of the regional league. The draw also listed the 248 clubs exempt at this stage, confirming that 934 teams from the region were taking part in the competition this season. The second round draw, consisting of 271 ties, and featuring the entry of all the remaining sides from the second and third levels of regional league, was published on 19 August 2025.
The third round draw, which totalled 155 ties, and featured the entry of the remaining teams from the regional league, and the three teams from Championnat National 3, was published on 2 September 2025. The fourth round draw, where the five teams from Championnat National 2 entered, was conducted separately in each of the three sectors of the region, over three days from 16 September 2025 to 18 September 2025. The fifth round draw took place on 1 October 2025. The sixth round draw was published on 15 October 2025.
First round These matches were played on 9, 14, 16, 17, 19 and 20 August 2025, with two postponed to 24 and 27 August 2025.