The 2025–26 Coupe de France preliminary rounds, Pays de la Loire was the qualifying competition to decide which teams from the leagues of the Pays de la Loire region of France took part in the main competition from the seventh round.
A total of eleven teams qualified from the Pays de la Loire preliminary rounds.
In 2024–25, Le Mans FC were the team from the region to progress furthest in the main competition, reaching the round of 16 before being beaten 2–0 by eventual champions Paris Saint-Germain FC.
Draws and Fixtures On 23 July 2025, the league published that 519 teams from the region had entered the competition, including the four teams qualifying directly for the main competition. At the same time, they confirmed the first round would consist of 200 ties, including 46 teams from Régionale 3 and all teams from the district level leagues. The first round draw was published by the league on 28 July 2025. The second round draw, which saw the entry of the remaining teams from Régional 3 and those from Régional 2, was published on 28 August 2025. The third round draw, featuring the entry into the competition of the 18 Régional 1 teams and the 7 Championnat National 3 teams, was published on 4 September 2025. The fourth round draw, which saw the 4 teams from the region that play in Championnat National 2 join the competition, was published on 17 September 2025. The fifth round draw was published on 2 October 2025. The sixth round draw was published on 15 October 2025.
First round These matches were played on 24 August 2025.