α-Pyrrolidinooctanophenone (α-POP) also known as PV9 — a central nervous system stimulant that exhibited properties of a neuroinflammatory agent.
Pharmacology Pharmacodynamics α-Pyrrolidinooctanophenone promotes activation of human microglial cells via a ROS/STAT3-dependent pathway.
Pharmacokinetics α-Pyrrolidinooctanophenone was metabolized into hydroxy-derivatives or oxidized by the liver to lactam, PV9 has an increased affinity for enzymes of the cytochrome P450 system, to the active centers of the isoforms CYP1A2, CYP2C9 and CYP2C19.
See also Substituted phenylethylpyrrolidine α-Pyrrolidinopropiophenone (α-PPP) α-Pyrrolidinobutiophenone (α-PBP) α-Pyrrolidinopentiophenone (α-PVP) α-Pyrrolidinohexiophenone (α-PHP) α-Pyrrolidinoheptaphenone (α-PHPP)
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