Eissa or Al-Eissa is a given name and surname. Notable people with the name include:
Surname Hamad Al-Eissa (born 1982), Saudi Arabian football player Ibrahim Eissa (born 1965), Egyptian journalist and TV personality Mohamed Eissa (born 1936), Egyptian rower Muhammad S. Eissa, American Arabist Nada Eissa, American economist Omar Eissa (born 1996), Egyptian swimmer Osama Al-Eissa (born 1963), Palestinian writer Seif Eissa (born 1998), Egyptian taekwondo practitioner Yaa'rab al-Eissa, Syrian writer and journalist
Given name Eissa Meer Abdulrahman (born 1967), Emirati footballer