Bunch of grapes sign, also written bunch-of-grapes sign, is a descriptive term in radiology for the appearance of multiple small, clustered cystic spaces on medical imaging. It has been applied to several conditions.
Bunch of grapes sign (uterus), in hydatidiform mole, where swollen chorionic villi form a uterine mass of many small cysts on ultrasound Bunch of grapes sign (pancreas), in intraductal papillary mucinous neoplasm of the pancreas, in which dilated side branches form a cluster of small cysts Bunch of grapes sign (kidney), in multicystic dysplastic kidney, where multiple non-communicating cysts give the kidney a grape-like cluster Bunch of grapes sign (lung), in bronchiectasis, where dilated cystic bronchi lying close together appear as clustered thin-walled cysts on chest imaging Bunch of grapes sign (soft tissue), in botryoid rhabdomyosarcoma, a polypoid tumour whose grape-like surface underlies the older name sarcoma botryoides
See also Bowl of grapes sign, a similarly named term for the cystic appearance of synovial sarcoma