Blood and Bone is a 2009 American martial arts film.

Blood and Bone may also refer to:

Blood and Bone (novel), 2012 novel by Ian Cameron Esselmont Blood and Bone (Hodgins collection), 1986 collection of poems by Philip Hodgins "Blood and Bone" (The Boys episode), 2026 episode and series finale of the television series The Boys

See also Children of Blood and Bone