Madjiguène or Madjiguene is the Frenchified spelling of the Wolof female given name Maajigéen (from ). Notable people with the name include:
Anna Madgigine Jai Kingsley (born Anta Madjiguène Ndiaye; 1793–1870), West African slave turned slave owner in Cuba Madjiguène Cissé (1951–2023), Senegalese immigrants rights activist Madjiguene Sene (born 1994), Senegalese basketball player Youssou "Madjiguène" N'Dour (born 1959), Senegalese singer, songwriter, musician and politician