7-Hydroxytryptamine (7-HT) is a serotonin receptor modulator of the tryptamine family. It is the 7-hydroxy derivative of tryptamine and is a positional isomer of serotonin (5-hydroxytryptamine; 5-HT).
The drug shows sympathomimetic effects similarly to serotonin. On the other hand, similarly to 6-hydroxytryptamine but in contrast to serotonin, it showed little or no activity as a serotonin receptor agonist in the rabbit thoracic aorta, which expresses serotonin 5-HT2 receptors. The drug is known to act as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), with greater potency on catecholamine reuptake than serotonin reuptake, whereas its possible effects in terms of monoamine release induction were not assessed. However, in other studies, 7-HT was reported to increase serotonin and norepinephrine release. It did not show the long-lasting monoaminergic neurotoxicity of certain related compounds like 5,7-dihydroxytryptamine (5,7-DHT) in rodents.
7-HT was first described in the scientific literature by Irvine Page by 1952.
See also Substituted tryptamine 4-Hydroxytryptamine (4-HT) 6-Hydroxytryptamine (6-HT) 7-Methoxytryptamine 7-Fluorotryptamine 7-Chlorotryptamine 7-Methyltryptamine 5,7-Dihydroxytryptamine (5,7-DHT) 7-Hydroxy-DMT 7-Methoxy-DMT
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