Mühe (German for "effort" or "toil") is a German surname. Notable people with the surname include:

Anna Maria Mühe (born 1985), German actress Charlotte Mühe (1910–1981), German swimmer Erich Mühe (1938–2005), German surgeon Karl-Heinz Mühe (1949–2026), German politician Ulrich Mühe (1953–2007), German actor

See also

de:Mühe it:Mühe ru:Мюэ