Lysergic acid 2-pentylamide (2-LSP), also known as N-(2-pentyl)lysergamide (N2Pe-LA), is a serotonin receptor modulator and possible psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). https://erowid.org/library/books_online/tihkal/tihkal26.shtml [...] "N-Pentan-2-yllysergamide" [...] It is a mixture of (R)- and (S)- enantiomers.
Both enantiomers of 2-LSP show affinity for the serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors, but (R)-2-LSP shows far greater affinity for these receptors in comparison. (R)-2-LSP had about the same affinity as LSD for the serotonin 5-HT2A receptor (Ki = 4.5–10nM; K0.5 = 0.99–1.0nM), but had 0.8- to 9-fold higher affinity than LSD for the serotonin 5-HT1A receptor (Ki = 0.6–1.4nM; K0.5 = 0.37nM). Both (R)- and (S)-2-LSP act as full agonists of the serotonin 5-HT2A receptor, but (R)-LSP is nearly 20-fold more potent than (S)-LSP in this regard () = 5.4nM (100%) and 91nM (100%), respectively). Both enantiomers are also serotonin 5-HT2C receptor agonists, with (R)-LSP likewise being much more active than (S)-LSP. (R)-2-LSP fully substituted for LSD in rodent drug discrimination tests, with about half the potency of LSD. Conversely, (S)-2-LSP did not substitute for LSD in these tests.
The chemical synthesis of 2-LSP has been described.
2-LSP was first described in the scientific literature by David E. Nichols and colleagues by 1995.
See also Substituted lysergamide Lysergic acid 2-butylamide (LSB) Lysergic acid 3-pentylamide (LSP, 3-LSP) Lysergic acid butylamide
References
External links 2-LSP - Isomer Design