The 1942 Southern Jaguars football team was an American football team that represented Southern University as a member of the Southwestern Athletic Conference (SWAC) during the 1942 college football season. Led by Ace Mumford in his seventh season as head coach, the Jaguars compiled an overall record of 4–4–1, with a mark of 0–3–1 in conference play, and finished fifth in the SWAC.

The team played its home games at University Stadium in Scotlandville, Louisiana (which has since been annexed into the Baton Rouge city limits).

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