Mains is a surname and may refer to:
David F. Mains (1874–1949), American politician from Wisconsin Edwin Butterworth Mains (1890–1968), American mycologist Geoffrey Mains (1934–2021), English cricketer Gil Mains (1929–2009), American football player Jim Mains (1922–1969), American baseball pitcher John Mains (1851–1901), Irish nationalist politician Laurie Mains (born 1946), New Zealand rugby union footballer and coach S. L. Mains (1865–1934), American college football player and coach Willard Mains (1868–1923), American baseball pitcher
See also Maines (surname) Main (surname) Manes (surname) Maynes McMains