Ekpenyong is a Nigerian surname of Ibibio and Efik origin which means "Lion of the river or sea". It could also mean "Lion from above"
Notable people with the surname Ita Ekpeyong (), Nigerian security officer Udeme Ekpeyong (born 1973), Nigerian sprinter Asuquo Ekpenyong (born 1985), Nigerian politician Keppy Ekpenyong, Nigerian actor Chris Ekpenyong (born 1954), Nigerian politician Nse Ekpenyong (born 1964), Nigerian politician Frank Ekpeyong, Nigerian politician Emmanuel Ekpeyong (born 2004), Nigerian footballer Janet Ekpeyong, Nigerian medical professional and public official Oku Ekpeyong, British campaigner
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