Jam Saifullah Khan Dharejo () is a Pakistani politician who has been a member of Senate of Pakistan from 2024 and member of Provincial Assembly of Sindh from 10 October 2002 to 15 November 2007.

Political career He was elected to Provincial Assembly of Sindh in 1988 from Constituency PS-3 Sukkur then again re-elected in 1997 from PS-4 Sukkur then again re elected in 2002 from PS-3 Sukkur then re-elected from the same seat in 2008. Dharejo was elected from Sindh province during the 2024 Pakistani Senate election as a Pakistan People's Party Parliamentarians candidate on a general seat.

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