In medicine, malaise is a feeling of discomfort.

Malaise may also refer to:

Malaise trap Malaise era, an era of poor-quality cars in the United States from the 1970s-1980s Post-exertional malaise Malaise Créole The Malaise of Modernity The Great Malaise Un Certain Malaise Malaise (surname), name list Malaise Castle Malaise speech Elephant Micah and the Agrarian Malaise