24H-NBOMe, also known as N-(2-methoxybenzyl)-2,4-dimethoxyphenethylamine (2,4-DMPEA-NBOMe), is a potent serotonin receptor modulator that is a positional isomer of 25H-NBOMe, in which the methoxy groups are substituted at the 2- and 4-positions of the phenethylamine moiety. This is an N-benzyl derivative of 2,4-dimethoxyphenylethylamine. It is a representative of the 24x-NBOMe series.
Pharmacology 24H-NBOMe is a potent serotonergic agent; primarily, it is a full agonist of the 5-hydroxytryptamine receptor 2A with a Ki value of 1.71–3.88 nM (In mice, this value was 0.68 nM.) 24H-NBOMe binds to the receptor approximately 174 times more strongly than 2,4-DMPEA.
24H-NBOMe is a substance that causes anxiety or panic and inhibits motor activity in zebrafish.
History 24H-NBOMe was first described by David Earl Nichols and his colleagues.
See also Substituted N-benzylphenethylamine
References
External links 24H-NBOMe - Isomer Design