Lewe is a surname. It may be Löwe spelled without diacritics or literally meaning 'life' or 'lion' is some Germanic languages. In particular, it is associated with the Dutch noble . Notable people with the surname include:
Barbara Lewe-Pohlmann-Schüttpelz or Barbara Schüttpelz Detlef Lewe (1743–1822) Dutch politician (died 1641), Dutch nobleman and statesman John Lewe (born 1992), German singer Sarah Marianne Corina Lewe, birth name of Sarah Connor (singer)
See also