Mercouris, Merkouris or Mercouri is a surname. Notable people with the surname include:
George S. Mercouris (1886–1943), Greek politician, Spyridon's son Melina Mercouri (1920–1994), Greek actress, singer, activist, and politician, Spyridon's granddaughter Stamatis Merkouris (1895–1967), Greek Army officer and politician, Spyridon's son Spyridon Mercouris (1856–1939), Greek politician