2CT2-2,5-DiEtO

2CT2-2,5-DiEtO, also known as 2,5-diethoxy-4-ethylthiophenethylamine, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to the psychedelic drug 2C-T-2. "The 2,5-DiEtO-homologue of 2C-T-2 is 2,5-diethoxy-4-ethylthiophenethylamine, or 2CT2-2,5DIETO. The benzaldehyde, 2,5-diethoxy-4-(ethylthio)benzaldehyde, had a melting point of 84–85 °C, the nitrostyrene intermediate a melting point of 123–124 °C, and the final hydrochloride a melting point of 220–221 °C. Levels that were evaluated from 10 to 50 milligrams were not particularly different in intensity, but were progressively longer in duration. At 50 milligrams there was a nervousness and edginess during the early part of the experience, but for the next several hours there was evident both energy and high attentiveness. There were few if any sensory alterations. There were no negatives on the following day. The duration was perhaps nine hours." It is the derivative of 2C-T-2 in which the methoxy groups at the 2 and 5 positions have been replaced with ethoxy groups.

According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CT2-2,5-DiEtO's dose is 10 to 50mg orally and its duration is approximately 9hours. The effects of 2CT2-2,5-DiEtO have been reported to include initial nervousness and edginess followed by energy and high attentiveness, few if any sensory alterations, and no next-day hangover. Higher doses across the range of 10 to 50mg orally were not particularly different in terms of intensity, but were progressively longer in duration. At 50mg orally, the duration was around 9hours.

The chemical synthesis of 2CT2-2,5-DiEtO has been described.

2CT2-2,5-DiEtO was first described in the literature by Shulgin in PiHKAL in 1991. It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.

2CT2-2,5-DiEtO

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