Mehaffey is a surname. Notable people with the surname include:

Blanche Mehaffey (1903–1968), American showgirl and film actress Carolyn Mehaffey (fl. 1980s), American rower Catherine Mehaffey (fl. 1970s–2000s), American attorney and crime suspect James Mehaffey (1931–2020), Bishop of Derry and Raphoe of the Church of Ireland Joseph Cowles Mehaffey (1889–1963), American military officer and engineer Olivia Mehaffey (born 1998), professional golfer from Northern Ireland

See also Mehaffey House, historic house in Little Rock, Arkansas Clan Macfie, Scottish clan of which Mehaffey is a sept Tom Mehaffie (born 1971), American politician Mehaffy, a surname