2CT-2-EtO, also known as 2-ethoxy-5-methoxy-4-methylthiophenethylamine, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to the psychedelic drug 2C-T. "Both of the homologous mono-ethoxy Tweetios of 2C-T have been synthesized and evaluated. The 2-EtO-homologue of 2C-T is 2-ethoxy-5-methoxy-4-methylthiophenethylamine, or 2CT-2ETO. The benzaldehyde (2-ethoxy-5-methoxy-4-(methylthio)benzaldehyde) was an oil, the nitrostyrene intermediate had a melting point of 137–138 °C, and the final hydrochloride a melting point of 215–216 °C. The effects were felt very quickly, and there was a blurring of vision. However, the highest dose tried, 50 milligrams, was not able to produce a greater-than-plus one state, and what did occur, lasted for only 4 hours." It is the derivative of 2C-T in which the methoxy group at the 2 position has been replaced with an ethoxy group.
According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CT-2-EtO's dose is 50mg orally and its duration is 4hours. It is said to have a "very quick" onset. The effects of 2CT-2-EtO are said to be "mild", reaching no greater than a "plus-one" on the Shulgin Rating Scale, and were reported to include blurred vision, with no other specific effects described. Higher doses of the drug were not assessed.
The chemical synthesis of 2CT-2-EtO has been described.
2CT-2-EtO was first described in the literature by Shulgin in PiHKAL in 1991. It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.
See also TWEETIO (psychedelics)
References
External links 2CT-2ETO - Isomer Design