Guilherme Santos Mello (born 9 June 1983) is a Brazilian economist, sociologist, and professor, who has served as Executive-Secretary of the Ministry of Planning and Budget since 2026. He also served as Secretary of Economic Policy at Brazil's Ministry of Finance from 2023 to 2026 under Minister Fernando Haddad. He is on leave from his position as a professor at the Institute of Economics (IE) of the State University of Campinas (Unicamp).

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