RU-29717, also known as N-propyl-9-oxaergoline or as 6-propyl-9-oxaergoline (POE), is a dopamine receptor agonist and serotonin receptor modulator of the 9-oxaergoline family closely related to ergolines such as pergolide.
It produces effects including suppression of prolactin secretion, hypotension, emesis, stereotypy, and antiparkinsonian-like effects in animals. In addition to its dopamine receptor agonism, RU-29717 shows affinity for serotonin receptors (e.g., 5-HT1 and 5-HT2 receptors), with much higher affinity for the serotonin 5-HT1 receptors than the related dopamine receptor agonist pergolide, though RU-29717's affinity for serotonin 5-HT2 receptors is much lower than for serotonin 5-HT1 receptors. Relatedly, RU-29717 also caused short-lasting head twitches in rodents, which were hypothesized to be due to serotonin receptor agonism. The head-twitch response is notable in being a behavioral proxy of psychedelic effects caused by serotonin 5-HT2A receptor agonism.
RU-29717 was described in the scientific literature in 1983 and was patented in 1985.
See also Substituted 9-oxaergoline 6-Ethyl-9-oxaergoline (EOE) Voxergolide (RU-41656) Descarboxylysergic acid
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