3C-FE, also known as 4-(2-fluoroethoxy)-3,5-dimethoxyamphetamine or as 3C-fluoroescaline, is a serotonin receptor modulator of the phenethylamine, amphetamine, and 3C families. It is the amphetamine (α-methyl) derivative of the psychedelic drug fluoroescaline (FE).
According to Daniel Trachsel in his book Phenethylamine: von der Struktur zur Funktion and other publications, 3C-FE is inactive at doses of up to 24mg orally, but has not been sufficiently investigated. Hence, its properties and effects in humans remain unknown.
The drug shows weak affinity for the serotonin 5-HT2A and 5-HT2C receptors (Ki = 5,987–12,000nM and 8,400–>10,000nM, respectively). It is an agonist of the serotonin 5-HT2A and 5-HT2B receptors ( () = 120nM (102%) and 800nM (29%), respectively).
The chemical synthesis of 3C-FE has been described.
3C-FE was first described in the scientific literature by Daniel Trachsel in 2002.
See also 3C (psychedelics)
References
External links 3C-FE - Isomer Design