Caines is a surname. Notable people with the surname include:
Cliff Caines, Canadian documentary filmmaker Crystal Caines, Guyanese–American rapper Daniel Caines (born 1979), English athlete Eleanor Caines (1870 or 1880–1913), American silent film actress Gavin Caines (born 1983), English footballer George Caines (1771–1825), the first official reporter of cases in the United States Helen Caines, American professor of physics Jeannette Caines (died 2004), American author of children's books John Caines (born 1933), English civil servant Justine Caines (1973–2022), Australian lobbyist and advocate Peter E. Caines (born 1945), Canadian engineer Wayne Caines, Bermudian politician
See also Caine (surname)