Phenylcyclopropylmethylamines (PCPMAs), or 2-phenylcyclopropylmethylamines, are a class of chemical compounds and drugs related to other groups such as phenethylamines and phenylcyclopropylamines (e.g., tranylcypromine, DMCPA).
Drugs of the PCPMA family include serotonin–norepinephrine reuptake inhibitors (SNRIs) (e.g., milnacipran), monoamine oxidase inhibitors (MAOIs), melatonin receptor agonists, neurokinin NK3 receptor antagonists, dopamine D2 receptor agonists, dopamine D3 receptor modulators, serotonin 5-HT2C receptor agonists (e.g., lumocaserin), and sigma σ1 receptor ligands, among others.
PCPMA itself is known to act as a potent and selective serotonin 5-HT2C receptor agonist (and to a lesser extent as a serotonin 5-HT2B receptor agonist), whereas tranylcypromine was more than 500-fold less potent as a serotonin 5-HT2C receptor agonist in comparison.
Chemical synthesis of 2-phenylcyclopropylmethylamines has been reviewed.
References