Francisco Aguirre (1910–1967) was a Cuban politician and trade unionist.
Francisco Aguirre may also refer to:
Francisco Aguirre de la Hoz (born 1943), Spanish lawyer and politician Francisco Aguirre (Paraguayan footballer) (1907–?), Paraguayan footballer Francisco Aguirre-Velasquez, Salvadoran activist for the rights of workers and immigrants in the United States
See also Francisco Aguirre Matos Mancebo, Dominican baseball player Francisco de Aguirre (disambiguation)