2CE-5-EtO, also known as 4-ethyl-2-methoxy-5-ethoxyphenethylamine or as Eternity, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to the psychedelic drug 2C-E. "[...] Ethylation of this material serves as the starting point for the synthesis of 2CE-5ETO. [...] One Tweetio of 2C-E is known. The 5-EtO-homologue of 2C-E is 5-ethoxy-4-ethyl-2-methoxyphenethylamine, or 2CE-5ETO. The nitrostyrene intermediate had a melting point of 110-110.5 °C, and the final hydrochloride a melting point of 184-185 °C. The effective level of 2CE-5ETO is in the 10 to 15 milligram range. It is gentle, forgiving, and extremely long lived. Some 3 to 4 hours were needed to achieve plateau, and on occasion experiments were interrupted with Valium or Halcion at the 16 hour point. After a night's sleep, there were still some effects evident the next day. Thus, the dose is comparable to the parent compound 2C-E, but the duration is 2 to 3 times longer. It was given the nickname "Eternity" by one subject." It is the derivative of 2C-E in which the methoxy group at the 5 position has been replaced with an ethoxy group.

According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CE-5-EtO's dose is 10 to 15mg orally and its duration is 16 to 24hours. It has a slow onset of 3 to 4hours to reach a plateau of effects and is described as extremely long-lived, with a duration 2 to 3times longer than that of 2C-E. The drug is said to be gentle and forgiving, but its effects were not otherwise described. Due to its very long duration, it has sometimes been counteracted with a benzodiazepine like diazepam or triazolam at the 16-hour point to allow sleep, but with effects still evident the next day. One subject gave it the nickname "Eternity".

The chemical synthesis of 2CE-5-EtO has been described.

2CE-5-EtO was first described in the literature by Shulgin in PiHKAL in 1991. It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.

See also TWEETIO (psychedelics)

References

External links 2CE-5ETO - Isomer Design